Fig. 2
Transcriptomic analysis of melanoma cells exposed to live Candida albicans at MOI 1 for six hours. (a) Volcano plot representing differentially-expressed genes (DEGs). Yellow dots represent upregulated genes. (b) GO enrichment analysis of the Biological Processes (GO-BP) significantly upregulated. (c) KEGG pathways significantly upregulated. (d) STRING performed with upregulated genes, their relationship (grey lines) and the KEGG pathways in which they are implicated (only interrelated genes are shown). Line thickness indicates the strength of data support. (e) Heat-maps showing the expression levels comparison between samples (Z-score) of DEGs: HIF-1 signaling pathways, central carbon metabolism in cancer, pathways in cancer and MAPK signaling pathways. Each column represent a biologically independent sample. Yellow and purple boxes represents upregulated and downregulated genes, respectively. (a–d) analysis were performed for │FC│ > 1.5 and padj ≤ 0.05 and, (e) analysis with padj ≤ 0.05 (iDEP 1.0 tool and Deseq2 method) (n = 3 biologically independent samples).
