Fig. 5
Analysis of AP-1 transcription factor activation by MOI 5 live Candida albicans in melanoma cells. Gene expression of Jund, Jun and Atf3 induced by six hours of stimulation with C. albicans alone or treated with (a–c) p38 inhibitor or (d,f,g) HIF-1α inhibitor. Data were presented as the individual values, means ± SEM. (a,d (n = 3 biologically independent samples); (b,c,e,f) (n = 4 biologically independent samples). Two-tailed unpaired Student’s t test was used to examine the statistical significance between groups. ## and ### denote P < 0.01 and P < 0.005 respect to control without C. albicans, respectively; * and ** denote P < 0.05 and P < 0.01 of each inhibitor compared to inhibitor with C. albicans, respectively; † and †††† denote P < 0.05 and P < 0.001 C. albicans group compared to inhibitors with C. albicans groups, respectively.
