Table 3 Mean difference and 95% CI of metabolite ratios in participants with chronic non-specific neck pain (n = 29) compared to pain-free controls (n = 26).
Brain region | Metabolite ratios | Left hemisphere | Right hemisphere | ||||
|---|---|---|---|---|---|---|---|
Mean difference (95% CI) | Adjusted p-value | ηp2 | Mean difference (95% CI) | Adjusted p-value | ηp2 | ||
DLPFC | Cho/tCr | 0.00 (− 0.03 to 0.03) | 0.84 | 0.00 | − 0.03 (− 0.07 to 0.02) | 0.46 | 0.03 |
mI/tCr | − 0.21 (− 0.33 to − 0.09) | 0.004 | 0.20 | 0.07 (− 0.17 to 0.30) | 0.78 | 0.01 | |
NAA/tCr | − 0.02 (− 0.20 to 0.16) | 1.00 | 0.00 | − 0.05 (− 0.26 to 0.16) | 0.63 | 0.01 | |
Glx/tCr | 0.19 (− 0.31 to 0.69) | 0.89 | 0.01 | − 0.77 (− 1.29 to − 0.26) | 0.02 | 0.15 | |
Insula | Cho/tCr | − 0.01 (− 0.05 to 0.02) | 0.94 | 0.01 | 0.01 (− 0.01 to 0.03) | 1.00 | 0.01 |
mI/tCr | − 0.03 (− 0.10 to 0.03) | 1.00 | 0.02 | − 0.03 (− 0.12 to 0.06) | 1.00 | 0.01 | |
NAA/tCr | 0.03 (− 0.13 to 0.19) | 0.96 | 0.00 | 0.03 (− 0.15 to 0.20) | 0.75 | 0.00 | |
Glx/tCr | − 0.00 (− 0.31 to 0.30) | 0.98 | 0.00 | 0.07 (− 0.27 to 0.42) | 0.90 | 0.00 | |
S1 | Cho/tCr | 0.05 (0.02 to 0.08) | 0.01 | 0.18 | − 0.01 (− 0.05 to 0.03) | 0.70 | 0.00 |
mI/tCr | − 0.04 (− 0.11 to 0.04) | 0.64 | 0.02 | − 0.02 (− 0.10 to 0.06) | 0.83 | 0.01 | |
NAA/tCr | 0.05 (− 0.17 to 0.28) | 0.85 | 0.01 | − 0.33 (− 0.51 to − 0.15) | < 0.001 | 0.22 | |
Glx/tCr | 0.02 (− 0.29 to 0.33) | 0.92 | 0.00 | − 0.07 (− 0.32 to 0.19) | 1.00 | 0.01 | |
Thalamus | Cho/tCr | 0.00 (− 0.04 to 0.04) | 0.96 | 0.00 | 0.03 (− 0.02 to 0.07) | 0.87 | 0.03 |
mI/tCr | − 0.14 (− 0.24 to − 0.04) | 0.03 | 0.14 | − 0.00 (− 0.11 to 0.10) | 0.96 | 0.00 | |
NAA/tCr | 0.03 (− 0.18 to 0.24) | 1.00 | 0.00 | 0.15 (− 0.09 to 0.40) | 0.44 | 0.03 | |
Glx/tCr | − 0.17 (− 0.56 to 0.23) | 0.80 | 0.02 | 0.16 (− 0.25 to 0.57) | 0.59 | 0.01 | |
