Table 4 Associations between FLNA and tumor characteristics and treatment outcomes.

From: Immunohistochemical analysis of filamin a expression in acromegaly and its correlation with tumor characteristics and treatment response

Tumor type

 

Macroadenoma

Microadenoma

p = 0.0186*

FLNA score 1

7 (53.8%)

4 (46.2%)

FLNA score 2

14 (100%)

0

FLNA score 3

5 (100%)

0

Suprasellar extension

 

present

absent

p = 0.0078*

FLNA score 1

4 (36.4%)

7 (63.6%)

FLNA score 2

12 (85.7%)

2 (14.3%)

FLNA score 3

5 (100%)

0 (0%)

Cavernous sinus invasion

 

present

absent

p = 0.5210

FLNA score 1

4 (36.4%)

7 (63.6%)

FLNA score 2

8 (57.1%)

6 (42.9%)

FLNA score 3

3 (60%)

2 (40%)

Sphenoidal sinus invasion

 

present

absent

p = 0.0715

FLNA score 1

0

11 (100%)

FLNA score 2

4 (28.6%)

10 (71.4%)

FLNA score 3

0

5 (100%)

Optic chiasm compression

 

present

absent

p = 0.7214

FLNA score 1

3 (27.3%)

8 (72.7%)

FLNA score 2

3 (21.4%)

11 (78.6%)

FLNA score 3

2 (40%)

3 (60%)

fgSRL response

 

responders

non-responders

p = 0.5199

FLNA score 1

5 (71.4%)

2 (28.6%)

FLNA score 2

5 (45.5%)

6 (54.5%)

FLNA score 3

2 (66.7%)

1 (33.3%)

Surgically cured

 

yes

no

p = 0.5361

FLNA score 1

2 (18.2%)

9 (81.8%)

FLNA score 2

3 (21.4%)

11 (78.6%)

FLNA score 3

0 (0%)

5 (100%)

  1. *- Chi-square test was applied, p < 0.05, FLNA- Filamin A.
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