Fig. 3
From: Identification and mechanism of key genes in inflammatory response of chronic otitis media in rats
Functional characterization of candidate inflammatory genes. (a) Gene Ontology (GO) enrichment analysis conducted using the clusterProfiler package showing biological process, cellular component, and molecular function categories (p.adj < 0.05). (b) KEGG pathway enrichment analysis of candidate genes using the clusterProfiler package (p.adj < 0.05). (c) Protein–protein interaction network constructed using the STRING database (confidence > 0.4) and visualized in Cytoscape. Nodes represent genes, and edges represent interactions (red indicates genes upregulated in CSOM, whereas light purple denotes downregulated genes). (d) Functional similarity analysis of candidate genes conducted using the GOSemSim package. The color intensity represents the similarity scores.
