Table 2 Molecular Docking parameters and binding energies of six drugs with IL6 Protein.

Target	Drug	Binding energy	center.x	center.y	center.z	size.x	size.y	size.z
IL6	Andrographolide	−6.1	0	−10	23	22	22	22
IL6	Atiprimod	−5.6	14	−31	0	24	24	24
IL6	Dilmapimod	−6.3	6	−24	18	22	22	22
IL6	Polaprezinc	−6.4	14	−31	0	19	19	19
IL6	VX-702	−6.9	14	−31	0	22	22	22
IL6	Ginseng	−4.6	14	−31	0	16	16	16

Note: Binding energies were calculated using the AutoDock Vina platform as described in the Methods section. Drug with three-dimensional structures were retrieved from the PubChem database, and the Il6 protein structure was obtained from the Protein Data Bank (PDB). Compounds with binding energy < − 6 kcal/mol were selected for visualization of the docking conformations. Lower binding energy values indicate stronger binding affinity.

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