Fig. 5

Identification of key transcription factors in microglial inflammatory response after ICH. Transcriptional regulatory network of microglia gene group Cluster 2 (A) and Cluster 10 (B). Regulon with score > 20 was selected for visualization, where the red diamond represented transcription factors, the blue oval represented target genes, and the line represented the co-expression association. (C). Gene ontology enriched biological processes for key transcription factors in Cluster 2. D. Significantly enriched KEGG pathways for key transcription factors in Cluster 2 (Kanehisa & Goto, 2000). E. Expression of key TFs in microglia subgroups.