Fig. 1
From: Diagnostic and prognostic biomarkers associated with histotype in advanced epithelial ovarian cancer
Transcriptional landscape and genetic variance in the advanced-stage EOC study cohort reclassified according to the 2020 WHO guidelines. (A) Sankey diagram visualizing the impact of histotype reclassification based on pathology (47% of cases reclassified according to WHO 2020). (B) PCA plot illustrating histotype-stratified clustering within the cohort. PCA was performed on variance-stabilized expression values from all annotated Ensembl gene IDs, as processed by DESeq2. (C) Heatmap with hierarchical clustering (Euclidian distance, Ward.D2 clustering criterion) of the top 500 most variable genes, stratified by cohort subtypes. Abbreviations: BOT: borderline tumor, CCC: clear cell carcinoma, EC: endometrioid carcinoma, HGSC: high-grade serous carcinoma, LGSC: low-grade serous carcinoma, MC: mucinous carcinoma, PCA: principal component analysis, WHO: World Health Organization.
