Fig. 5
From: Diagnostic and prognostic biomarkers associated with histotype in advanced epithelial ovarian cancer
Histotype-specific prognostic genes associated with overall survival (OS). Kaplan-Meier (KM) survival curves for the top-ranked (A-D) unfavorable (HR > 1) and (E-H) favorable (HR < 1) outcome biomarkers in each histotype (HGSC, CCC, MC, and EC), based on OS. Log-rank test p-values and histotype-specific risk tables are provided for each curve, illustrating the prognostic significance of these biomarkers. Displayed adj.HR has been adjusted using the Benjamini-Hochberg model. High and low strata groups are dichotomized based on z-transformed expression data for each respective gene. HR values were adjusted by tumor stage, age at diagnosis, debulking surgery status, and initial treatment response after LASSO-selection of the covariates. Abbreviations: CCC: Clear cell ovarian carcinoma, CI: Confidence interval, DSS: Disease-specific survival, EC: Endometrioid ovarian carcinoma, HGSC: High-grade serous ovarian carcinoma, HR: Hazard ratio, MC: Mucinous ovarian carcinoma, OS: Overall survival. Note: Full DSS analyses, including additional KM plots are provided in Supplementary Fig. 3.
