Fig. 6 | Scientific Reports

Fig. 6

From: METTL3-mediated m6A modification of LINC00857 enhances stemness and metastasis of ovarian cancer cells by activating the YAP-TEAD pathway

Fig. 6

LINC00857 reverses the effect of down-regulation of METTL3 on YAP1. (A) Representative protein bands of YAP1, p-YAP1, LATS1 and TEAD4 in OVCAR8 cells across groups. (B) Quantification of protein expression levels normalized to GAPDH. Data were presented as mean ± SD (n = 3); **p < 0.01 vs. NC; ##p < 0.01 vs. si-METTL3; statistical analysis was performed using one-way ANOVA followed by Tukey’s post hoc test. METTL3, methyltransferase-like 3; YAP1, yes-associated protein 1; p-YAP1, phosphorylated-YAP1; LATS1, large tumor suppressor 1; TEAD4, TEA domain transcription factor 4.

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