Fig. 5 | Scientific Reports

Fig. 5

From: Ethylenediaminetetraacetic acid conjugated with polyethylene glycol is a safe chelator for colonic epithelial denudation and intestinal epithelial replacement therapy

Fig. 5

De-epithelialization efficiency of EDTA and E-PEGs in a proximal colon perfusion model. (a) Schematic representation of the laparotomy mouse model for proximal colon perfusion. (b) An image demonstrating the proximal colon perfusion procedure. (c) Representative images of the targeted colon after perfusion (scale bars, 1 mm). Arrowheads indicate the light-transmissive areas. (d) Measurement of the light-transmissive areas after 10 mM EDTA, 10 mM E-PEGs, and water (control) perfusion for 5 min (n = 5). (**P < 0.01, *** P < 0.001). (e) Measurement of the light-transmissive areas after 10 mM E-PEG4 and water (control) perfusion for 7.5 min (n = 5). Data are expressed as the mean ± SEM. ND: not detected.

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