Fig. 5

Meloxicam (MEL) treatment via drinking water (d.w.) is associated with slightly decreased wheel running activity in mice. (a) Running time (min), (b) running distance (km) and (c) average running velocity (km/h) is shown normalized to total time (h) during read out intervals (8 h during day and 16 h during night) for male (upper graphs) and female (lower graphs) mice. Running wheel data were documented between 8 and 9 am in the morning and between 4 and 6 pm in the afternoon. Data are shown as mean ± SD (n = 7 cages per sex, 3 mice/cage). Two-way ANOVA and Šídák’s multiple comparisons test reveals decrease in wheel running time and distance in mice at singular timepoints under MEL (20 mg/kg/24 h) treatment (*p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001). BL2, baseline 2.