Table 1 Noncompartmental analysis of pharmacokinetic parameters after subcutaneous injection of 5 mg/kg meloxicam in mice (n = 21 male, 21 female).

From: Suitability of prolonged meloxicam treatment in mice seems limited due to unfavorable pharmacokinetics, side effects, and impact on home-cage behaviors

Parameter

Unit

Mean

SD

Cmax

ng/mL

6,640.0

1,610.0

Tmax

h

1.50

0.55

T1/2

h

2.32

0.28

AUC 0 → ∞

h/ng/mL

21,080.0

5,430.0

AUMC 0 → ∞

h2/ng/mL

67,140.0

18,190.0

MRT 0 → ∞

h

3.19

0.29

Vd/F

mL/kg

845.76

263.62

CL/F

mL/h/kg

251.52

67.76

  1. Cmax, maximum plasma concentration; Tmax, time of maximum plasma concentration; T1/2, plasma elimination half-life; AUC 0 → ∞ , area under the curve from time 0 extrapolated to infinity; AUMC 0 → ∞ , area under the first moment curve from time 0 extrapolated to infinity; MRT 0 → ∞ , mean residence time from time 0 extrapolated to infinity; Vd/F, volume of distribution; CL/F, clearance.
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