Fig. 1 | Scientific Reports

Fig. 1

From: A design for an efficient functional panel that determines platelet exhaustion levels to differentiate responder and non-responder ITP patients

Fig. 1The alternative text for this image may have been generated using AI.

Assessment of platelet basal activation state and its functional competence in ITP patients and controls. (A) P-selectin expression, (B) PAC-1 binding, (C) and ROS generation in individuals with ITP (blue) compared to healthy controls (gray) at baseline and after agonist treatment. Red asterisks show statistical differences of each agonist group vs., the related base group, while black asterisks illustrate statistical differences between ITP (n = 28) and control (n = 20). *P <.05, **P <.01, and ***P <.001. Data presented as mean ± SD. CCCP, carbonyl cyanide m-chlorophenylhydrazone; PMA, Phorbol 12-Myristate 13-Acetate; ROS, Reactive Oxygen Species.

Back to article page