Fig. 3 | Scientific Reports

Fig. 3

From: A design for an efficient functional panel that determines platelet exhaustion levels to differentiate responder and non-responder ITP patients

Fig. 3The alternative text for this image may have been generated using AI.

Assessment of platelet basal activation state and its functional competence in ITP patients with respect to platelet count. (A) The correlation of platelet counts with P-selectin expression, (blue) PAC-1 binding, and (green) ROS generation (red) at baseline and (B) response to PMA states were analyzed in ITP patients (n = 28). Further, patients were divided into two PLT count groups (with a cutoff point of 30 × 103/µL). Then, (C) P-selectin expression, (D) PAC-1 binding and (E) ROS generation at baseline (blue) and in response to PMA (red) were evaluated. Black asterisks illustrate statistical differences between BS groups of ITP at baseline and after agonist treatment. *P <.05, **P <.01, and ***P <.001. Data presented as mean ± SD. CCCP, carbonyl cyanide m-chlorophenylhydrazone; PMA, Phorbol 12-Myristate 13-Acetate; ROS, Reactive Oxygen Species.

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