Table 4 Treatment response with respect to platelet activation status in ITP patients.
Characteristics | Group | N | Mean ± SD | Median (Min-Mix) | P-value* | AUC (95%CI) | Cut-off value | Sensitivity | Specificity |
|---|---|---|---|---|---|---|---|---|---|
Age | Non-responder | 20 | 17.75 ± 10.01 | 12.50 (10–39) | 0.013 | 80.6 (64.5–96.8) | 16.5 | 100 | 60.0 |
Responder | 8 | 28 ± 9.04 | 28.50 (17–40) | ||||||
P-selectin (Base) | Non-responder | 20 | 2.59 ± 1.53 | 1.93 (1.18–6.45) | 0.013 | 80.9 (65.0–96.9.0.9) | 1.745 | 100 | 65.0 |
Responder | 8 | 1.43 ± 0.22 | 1.50 (1.02–1.66) | ||||||
PAC-1 (Base) | Non-responder | 20 | 1.88 ± 0.31 | 1.79 (1.56–2.9) | 0.919 | 51.6 (25.0–78.1.0.1) | 1.88 | 75.0 | 40.0 |
Responder | 8 | 1.88 ± 0.33 | 1.77 (1.55–2.43) | ||||||
ROS (Base) | Non-responder | 20 | 1.64 ± 0.48 | 1.51 (1.07–2.88) | 0.334 | 62.2 (37.0–87.4.0.4) | 2.05 | 50.0 | 85.0 |
Responder | 8 | 1.87 ± 0.56 | 1.82 (1.17–2.7) | ||||||
P-sel (PMA) | Non-responder | 20 | 3.5 ± 1.1 | 3.27 (2–5.68.68) | 0.036 | 79.7 (62.0–97.3.0.3) | 3.36 | 100.0 | 55.0 |
Responder | 8 | 5.17 ± 1.79 | 4.58 (3.39–8.52) | ||||||
PAC-1 (PMA) | Non-responder | 20 | 2.31 ± 0.35 | 2.38 (1.61–2.8) | 0.006 | 84.1 (68.6–99.5) | 2.625 | 75.0 | 85.0 |
Responder | 8 | 3.26 ± 1.09 | 2.70 (2.45–5.45) | ||||||
ROS (PMA) | Non-responder | 20 | 5.75 ± 1.25 | 5.54 (3.62–7.89) | 0.011 | 85.6 (69.5–100.0) | 8.02 | 62.5 | 100.0 |
Responder | 8 | 7.86 ± 1.74 | 8.57 (5.5–9.6) | ||||||
PLT count | non-responder | 20 | 55.2 ± 41.98 | 44.00 (12–171) | 0.016 | 79.4 (60.5–98.2) | 50.5 | 87.5 | 60.0 |
Responder | 8 | 119.88 ± 74.14 | 99.00 (36–207) |
