Fig. 5 | Scientific Reports

Fig. 5

From: Bone marrow mesenchymal stem cells-derived exosomes protect against β-cell destruction models and kidney injury by suppressing ferroptosis

Fig. 5The alternative text for this image may have been generated using AI.

BMSC-EXOs therapy suppresses ferroptosis and repairs mitochondrial and tubular damage in STZ-Induced diabetic kidney injury. (A) TEM images showing mitochondrial morphology in renal tissues. Immunohistochemical staining for GPX4 in the glomerular and tubular regions of the kidney. Red asterisks in (A) indicate positive GPX4 expression in the glomeruli. And immunohistochemical staining for KIM1 in different groups. (B) Western blot analysis of GPX4 expression in kidney tissues, with quantification normalized to β-actin. (C) Quantification of relative iron content and (D) MDA levels in renal tissues. Each bar represents the mean ± SD of the data derived from five independent experiments (n = 5). *p < 0.05 versus STZ + PBS group. GPX4 glutathione peroxidase 4, KIM1 kidney injury molecule 1, MDA malondialdehyde, TEM transmission electron microscopy.

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