Fig. 3 | Scientific Reports

Fig. 3

From: Multivariate genome-wide analysis reveals shared genetic architecture and brain structural correlates of human cognitive abilities

Fig. 3The alternative text for this image may have been generated using AI.Fig. 3The alternative text for this image may have been generated using AI.

Regional association plots for cognitive ability lead SNPs identified by genomic structural equation modeling. LocusZoom plots displaying regional association signals for six representative lead SNPs from the cognitive ability GWAS. Each panel shows the -log₁₀ (P-value) for SNPs (y-axis) plotted against chromosomal position (x-axis), with recombination rate overlaid as a blue line. Lead SNPs are indicated by purple diamonds, and surrounding SNPs are color-coded according to linkage disequilibrium (LD) with the lead variant (r2 values: 0.0–0.2 in cyan, 0.2–0.4 in green, 0.4–0.6 in orange, 0.6–0.8 in orange-red, 0.8–1.0 in red). Gene annotations are shown below each plot. (A) rs589104 on chromosome 11 near GRIA4, MSANTD4, and ARS2LIPPT genes. (B) rs394059 on chromosome 5 near KCNN2. (C) rs17607537 on chromosome 6 near NEDD9, TMEM112B, and ADTRP. (D) rs17504520 on chromosome 18 near DCC. (E) rs6706409 on chromosome 2 in a gene-rich region including RAB11FIP5, NCD, FBXO41, EGR4, SMG05, PPADC1, CCT7, and ALMS1. (F) rs951901 on chromosome 12 near METL1, METL21B, TSEN, AVIL, XRC2C8SP1, and CYP2C cluster. The plots demonstrate clear association peaks with distinct LD patterns supporting the statistical significance of identified lead variants.

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