Fig. 4 | Scientific Reports

Fig. 4

From: Multivariate genome-wide analysis reveals shared genetic architecture and brain structural correlates of human cognitive abilities

Fig. 4The alternative text for this image may have been generated using AI.

Manhattan plot from FUMA-based assessment of cognitive ability structural equation model. Manhattan plot displaying MAGMA gene-based association results for cognitive abilities. The analysis tested 16,129 protein-coding genes using MAGMA implemented in FUMA software. The x-axis shows chromosomal positions (chromosomes 1–22), and the y-axis represents -log₁₀ (P-values) for gene-level association strength. Points are color-coded alternately (green and blue) by chromosome. The red dashed line indicates the Bonferroni-corrected significance threshold (P = 0.05/16,129 = 3.1 × 10–6, corresponding to -log₁₀ (P) ≈ 5.5), accounting for multiple testing across all genes analyzed. The green dotted line shows nominal significance (P = 0.05, corresponding to -log₁₀ (P) ≈ 1.3). The analysis identified 303 genes passing the Bonferroni-corrected threshold, which were used for subsequent pathway enrichment analysis. Gene-level associations complement the 206 independent genomic risk loci identified in SNP-level analysis.

Back to article page