Fig. 1
From: Discovery of a Proteolysis Targeting Chimera for TRKA and RET-derived oncoproteins
(A) Mechanism of action of PROTACs. (B) Chemical structure and key elements of PROTAC RET/TRKA degraders. The left end of each chemical linker is attached to Pz-1 and the right end is attached to E3 ligase ligand. The conjugation sites between the chemical linker and Pz-1 or E3 ligase ligand are shown as wavy lines.
