Fig. 1 | Scientific Reports

Fig. 1

From: The slow delayed rectifier K+ current is differently regulated under baseline conditions and following β-adrenergic stimulation in canine ventricular cardiomyocytes

Fig. 1

Effect of 10 nM isoproterenol (ISO) and 1 µM nisoldipine (NISO) on IKs in canine ventricular cardiomyocytes. (A, B) Command action potentials (above), representative averaged IKs current traces (below), and IKs time to peak values (inserts below) obtained under APVC conditions in untreated control (black), in the presence of 10 nM ISO (violet), and 1 µM NISO (blue). (C, D) Current–voltage relationships obtained from the experiment shown on panel A and B (untreated control: black, ISO: violet, NISO: blue). Red curves were generated by scaling the control traces up or down to the amplitude of those obtained with ISO or NISO, respectively. On the relative scale, 100% is the maximal current density obtained either in CTRL (red) and in ISO (violet) (C), or in CTRL (red) and NISO (blue) (D).

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