Fig. 2
Effect of pretreatment with 1 µM nisoldipine (NISO), 1 µM KN-93, 3 µM H-89 or KN-93 + H-89 on the isoproterenol (ISO) induced changes in IKs. (A) Command action potential (above) and representative averaged IKs current traces (below) obtained under APVC conditions in untreated controls, in the presence of 10 nM ISO, and in the further 4 groups when ISO was applied after pretreatment with 1 µM NISO, 1 µM KN-93, 3 µM H-89, or KN-93 + H-89. (B) Mid-plateau current densities, (C) peak current densities, (D) current integrals under the conditions on panel (A). Symbols and bars represent mean ± SEM, small dots represent individual data, numbers in parentheses indicate the number of cells studied. Asterisks indicate significant differences (p < 0.05) between groups determined using Dunnett’s post-hoc test comparing data to the ISO group.
