Table 5 Toxicity of different doses of vaginal wash (VW), Chitosan nanoparticles (Chit), and vaginal wash doped with Chitosan nanoparticles (VW + Chit) against SKOV3.

From: Innovative vaginal wash formulation with Chitosan nanoparticles targets microbial pathogens, ovarian cancer and inflammation

Concentration (µg/mL)

Toxicity (%)

VW

Chit

VW + Chit

0.0

0.00 ± 0.00a

0.00 ± 0.00a

0.00 ± 0.00a

31.25

0.19 ± 0.02a

0.00 ± 0.00a

0.00 ± 0.00a

62.5

7.24 ± 0.11a

0.00 ± 0.00c

0.14 ± 0.01b

125

46.36 ± 0.87b

45.05 ± 0.65b

50.75 ± 1.02a

250

78.99 ± 1.45c

95.24 ± 0.93a

96.83 ± 0.88a

500

96.97 ± 0.52a

95.89 ± 0.77a

97.06 ± 0.66a

1000

97.15 ± 0.33a

96.55 ± 0.42a

97.43 ± 0.57a

IC50 µg/mL

160.8 ± 1.57a

152.24 ± 0.51b

147.3 ± 0.65c

  1. Different superscript letters (a, b, c) in the same row indicate statistically significant differences among treatments (p < 0.05). Data are presented as mean ± SD, n = 3.