Fig. 1 | Scientific Reports

Fig. 1

From: Increase of intracellular Zn2+ concentration directly inhibits phospholipase Cε and suppresses inflammation and tumour formation in mice

Fig. 1

Identification of ZPT as an ε-Class Specific PLC Inhibitor. (A) Chemical structures of ZPT and Compound 1. (B) The activities of varying concentrations of ZPT to inhibit the hydrolysis of Compound 1 by purified PLCε, PLCβ4, PLCδ1 or PLCγ1 were measured as described in Methods. The experiments were performed three times in duplicates. (C) The activities of varying concentrations of ZPT to inhibit the hydrolysis of biotin-PIP2 by purified PLCε were measured as described in Methods. The experiments were performed three times.

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