Table 1 Inhibitory effects of 41 compounds on PLC isoforms ε, β4, δ1 and γ1.
Name | ε | β4 | δ1 | γ1 | Name | ε | β4 | δ1 | γ1 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|
1 | 6 | 1.2 | 0.7 | 0.5 | 1.3 | 22 | 53 | 7.9 | 2.4 | 1.2 | 2.1 |
2 | 21 | 1.4 | 2.4 | 1.4 | 2.4 | 23 | 67 | 9.0 | 10.1 | 6.1 | 7.2 |
3 | 11 | 1.6 | 2.3 | 2.7 | 2.4 | 24 | 63 | 1.3 | 0.9 | 1.6 | 1.3 |
4 | Sanguinarine | 1.9 | 79.7 | 47.8 | 1.6 | 25 | 9 | 2.9 | 3.9 | 3.4 | 4.6 |
5 | 27 | 2.2 | 2.6 | 2.6 | 1.7 | 26 | 36 | 3.2 | 0.3 | 2.1 | 0.5 |
6 | 17 | 2.3 | 2.4 | 1.1 | 2.3 | 27 | 40 | 3.4 | 3.7 | 3.0 | 3.2 |
7 | 74 | 2.5 | 2.4 | 1.5 | 2.4 | 28 | 78 | 3.4 | 2.5 | 2.4 | 2.5 |
8 | 33 | 2.5 | 2.4 | 1.5 | 2.4 | 29 | 33 | 3.4 | 3.8 | 3.6 | 4.6 |
9 | 66 | 2.9 | 2.5 | 2.2 | 1.6 | 30 | 48 | 3.9 | 4.3 | 2.6 | 4.3 |
10 | 1 | 3.1 | 3.7 | 0.4 | 8.7 | 31 | 25 | 3.9 | 3.5 | 3.0 | 4.1 |
11 | 59 | 3.1 | 2.5 | 2.5 | 2.5 | 32 | 41 | 4.5 | 2.0 | 1.9 | 3.7 |
12 | 19 | 3.1 | 2.5 | 1.9 | 2.5 | 33 | 73 | 4.7 | 3.2 | 35.4 | 1.8 |
13 | 75 | 3.3 | 2.6 | 1.3 | 2.6 | 34 | 2 | 4.9 | 4.6 | 5.8 | 1.9 |
14 | 46 | 3.3 | 4.8 | 2.6 | 9.2 | 35 | 38 | 5.2 | 5.0 | 3.1 | 6.1 |
15 | 28 | 3.4 | 3.9 | 3.0 | 4.6 | 36 | ZPT | 1.2 | > 50 | > 50 | > 50 |
16 | 58 | 3.4 | 3.2 | 2.9 | 3.4 | 37 | 89 | 5.4 | 26.5 | 14.9 | 3.8 |
17 | 45 | 4.1 | 2.9 | 2.1 | 4.4 | 38 | 75 | 6.1 | 5.6 | 3.6 | 3.0 |
18 | 31 | 4.6 | 4.7 | 3.9 | 4.3 | 39 | 20 | 7.1 | 9.1 | 4.7 | 13.2 |
19 | 73 | 4.8 | 8.3 | 3.6 | 8.6 | 40 | 7 | 3.5 | 8.5 | 2.1 | 3.5 |
20 | 32 | 5.1 | 5.0 | 4.7 | 9.7 | 41 | 70 | 9.0 | 7.0 | 12.8 | 4.7 |
21 | 20 | 5.4 | 6.5 | 4.0 | 13.1 |
