Table 6 Brief description of the genes with the highest DC.

From: Decoding the anti-inflammatory properties of sesquiterpene coumarins from the active fractions of Ferula assa-foetida through integrated experimental and in silico analyses

Gene symbol

Description

DC

HSP90AA1

Heat shock protein 90 alpha family class A member 1. Chaperone protein that aids in folding other proteins. Found to promote inflammation and immune cell activation18,19

12

NR3C1

Nuclear receptor subfamily 3 group C member 1. Encodes glucocorticoid receptor, which is known to be involved in inflammatory responses and cellular proliferation20,21

11

APP

Amyloid beta precursor protein. Encodes the bases of amyloid plaques, which were found to have synergistic pro-inflammatory activity22,23

11

ABL1

ABL proto-oncogene 1. Encodes a protein kinase involved in cell division and adhesion. Also modulates innate immunity by regulating ubiquitination of other proteins24

10

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