Fig. 4

(a and e) show 3a (blue), 3b (green) and 3c (purple) occupying the active site groove of AChE (4EY7) and BuChE (7Q1O), respectively. (b, c and d) show the binding mode of 3a, 3b and 3c with 4EY7, respectively. (f, g and h) show the binding mode of 3a, 3b and 3c with 7Q1O, respectively.