Table 5 IC50 of tested compounds on AChE, BuChE, LOX5, iNOS, NO and RBC lysis.

From: Design and synthesis of 1,2,3-triazole thiadiazole hybrids with in vitro and in silico evaluation of their anti-inflammatory and anti-alzheimer activities

Compounds

AChE

BuChE

LOX5

NO

iNOS

RBC lysis

3a

57.61 ± 0.168d

71.11 ± 1.278h

6.37 ± 1.295b

63.08 ± 0.199c

6.28 ± 0.928c

213.96 ± 0.088e

3b

40.46 ± 0.051c

58.68 ± 0.832f.

20.52 ± 0.811d

171.24 ± 0.159f.

14.24 ± 0.774f.

322.98 ± 0.129g

3c

78.75 ± 0.125e

67.53 ± 0.856g

16.08 ± 0.847c

125.56 ± 0.204e

10.73 ± 0.849e

290.28 ± 0.074f.

N-3a

43.78 ± 0.069c

29.81 ± 0.794d

3.72 ± 0.842a

45.42 ± 0.166b

4.37 ± 0.602a

141.51 ± 0.261a

N-3b

44.31 ± 0.117c

25.95 ± 1.759c

2.56 ± 0.992a

68.25 ± 0.108c

6.28 ± 1.582c

172.04 ± 0.159c

N-3c

57.35 ± 0.063d

48.33 ± 0.637e

3.31 ± 0.669a

73.71 ± 0.192d

8.17 ± 0.706d

166.68 ± 0.207b

Reference drugs

 Donepezil HCl

12.87 ± 2.945a

18.37 ± 1.592b

    

 Rivastigmine

23.69 ± 1.742b

5.88 ± 1.855a

    

 Zileuton

  

3.74 ± 0.561a

   

 S-Ethylisothiourea

    

5.98 ± 0.737b

 

 Ascorbic acid

   

29.14 ± 0.973a

  

 diclofenac K

     

202.73 ± 1.673d

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