Table 2 Pharmacokinetic modeling of oxaliplatin release from nanomicelles.
From: Integrating machine-learning and nanotechnology to quantify pH-modulated oxaliplatin release
Model | Equation | R² (pH 5.4) | R² (pH 7.4) |
|---|---|---|---|
Zero-order | Ct = k0t | 0.8834 | 0.8498 |
First-order | ln (1- Mt/M∞) = k1t | 0.8965 | 0.0577 |
Higuchi | Q = kHt0.5 | 0.9475 | 0.9717 |
Hixson-Crowell | (1- Mt/M∞)1/3 = kHCt | 0.8521 | 0.8521 |
Baker-Lonsdale | Mt/M∞ = kBtn | 0.7995 | 0.5388 |
Korsmeyer-Peppas | ln (Mt/M∞) = nlnt + k | 0.9720 | 0.9600 |
