Fig. 1 | Scientific Reports

Fig. 1

From: Reduced Fc-mediated antibody responses after COVID-19 mRNA vaccination in a cohort of people living with HIV-1

Fig. 1The alternative text for this image may have been generated using AI.

Total immunoglobulin (Ig) responses against SARS-CoV-2 (A) and HIV-1 (B) in sera of PLWH vs. PWOH after COVID-19 mRNA vaccinations. Total Ig responses against SARS-CoV-2 (spike, RBD, S1, S2, and nucleoprotein) (A) and HIV-1 (AE.A244 gp120, M.Cons gp120, and B.HXB2 p24) (B) antigens were measured in titrated sera from 37 PLWH (circles) vs. 24 PWOH (triangles). Sera were collected after three COVID-19 mRNA vaccinations (median: 5- and 5.7-months post vaccination for PLWH and PWOH, respectively). Pre-pandemic samples were tested as a negative control for the SARS-CoV-2 antigens while the PWOH samples were used as a negative control for the HIV-1 antigens. The percentages of responders above the cut-off values (based on negative control mean + 3SD) were indicated for each antigen. Dotted line: negative control mean + 3SD. Red line: median. AUC: area under the titration curve. ****, p < 0.0001; ***, p < 0.001; *, p < 0.05; ns p ≥ 0.05 by two-tailed Mann-Whitney test. Open symbols represent individuals with high-level anti-nucleoprotein total Ig.

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