Fig. 3 | Scientific Reports

Fig. 3

From: Reduced Fc-mediated antibody responses after COVID-19 mRNA vaccination in a cohort of people living with HIV-1

Fig. 3The alternative text for this image may have been generated using AI.

Neutralization levels in sera of PLWH vs. PWOH after COVID-19 mRNA vaccination. (A) Neutralization was measured using recombinant VSV expressing spike glycoproteins of Wuhan, XBB.1.5, EG.5.1 and JN.1 SARS-CoV-2 strains. The period of sample collection relative to the timeline of variant emergence is presented. Sera from 36 PLWH vs. 24 PWOH after three COVID-19 mRNA vaccinations were serially diluted to determine 50% inhibitory dilution (ID50) titers against each virus strain. (B) Neutralization potencies were determined by calculating the ratios of ID50 titers over spike-total Ig levels. Red lines denote median values. *** p < 0.001; ** p < 0.01; * p < 0.05 by Mann-Whitney test. Open symbols represent individuals with high-level anti-nucleoprotein total Ig.

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