Fig. 2

Bacteremia cases have an altered inflammatory response in bacteremia. (A) Heatmap of protein expression levels in 84 bacteremia cases, ordered by statistical significance. Columns representing proteins with significantly higher odds ratios in cases compared to controls are marked in red, while those with significantly lower odds ratios are marked in blue. Proteins without statistically significant differences are marked in grey. Red indicates high relative expression, and blue indicates low relative expression for each protein. Color scales have been normalized separately for each protein, with the range adjusted between the lowest and highest expression values. (B) Volcano plot representing the p-values (–log10 scale) and average fold changes (log2 scale) of protein expression levels. Upregulated proteins (red) with the lowest p-values, highest fold changes, and highest odds ratios, as well as all downregulated proteins (blue), are indicated in the figure. The dotted line represents the p-value threshold of 0.05 (approximately 1.30). Note that ARTN is not included in the graph due to a negative average expression value in the control group, which results in a complex number for the log2 fold change.