Table 1 Combined cohort characteristics.

From: Novel polygenic risk score associates with diverticulitis in a multi-institutional, ancestrally diverse cohort

Characteristic

Total

PRS Deciles 1-92

Top PRS Decile

p-value3

Sample Size

N

36077

32471

3606

 

Diverticulosis only

 Yes

29694 (82.3%)

27076 (83.4%)

2618 (72.6%)

<0.001

Non-severe Diverticulitis

 Yes

5306 (14.7%)

4534 (14.0%)

772 (21.4%)

<0.001

Severe Diverticulitis

 Yes

1077 (3.0%)

861 (2.7%)

216 (6.0%)

<0.001

Diverticulitis (Total)

 Yes

6383 (17.7%)

5395 (16.6%)

988 (27.4%)

<0.001

Sex

 Male

16861 (46.7%)

15241 (46.9%)

1620 (44.9%)

.022

Age, years

 Mean (SD)

70.0 (± 12.0)

70.2 (± 12.0)

67.9 (+12.6)

<0.001

Ancestry

 African

3017 (8.4%)

2633 (8.1%)

384 (10.6%)

<0.001

 European

32638 (90.5%)

29456 (90.7%)

3182 (88.2%)

 

 Other

422 (1.2%)

382 (1.2%)

40 (1.1%)

<0.001

Body Mass Index

 Mean (SD)

31.0 (± 6.7)

30.9 (+ 6.7)

31.4 (± 6.9)

<0.001

 Missing

33 (0.1%)

32 (0.1%)

1 (0.0%)

.250

Smoker

 Yes

19321 (53.6%)

17334 (53.4%)

1987 (55.1%)

0.51

 Missing

1 (0.0%)

1 (0.0%)

0 (0.0%)

1.00

Type II Diabetes Mellitus

 Yes

15467 (42.9%)

13866 (42.7%)

1601 (44.4%)

.051

  1. 1 Cohort combines PMBB, BioVU, and MyCode data.
  2. 2 PRS: Polygenic Risk Score.
  3. 3 P-values calculated using t-tests for continuous variables and Fisher’s exact tests for categorical variables.