Fig. 2 | Scientific Reports

Fig. 2

From: FAM172A promotes epithelial ovarian cancer progression and induces platinum resistance via the PI3K/AKT pathway

Fig. 2The alternative text for this image may have been generated using AI.

Role of FAM172A in apoptosis and cisplatin resistance of EOC cells. (A) Flow cytometry analysis of apoptosis in EOC cells after FAM172A upregulation or knockdown. (B) Western blot analysis of apoptosis-related proteins. (C) Correlation between FAM172A expression and cisplatin IC₅₀ values. (D) Western blot analysis of FAM172A expression in A2780, SKOV3, and OVCAR-3 cells treated with increasing concentrations of cisplatin. (E) Cell viability measured by CCK-8 assay in EOC cells with modulated FAM172A expression under cisplatin treatment. (F) IC₅₀ values of cisplatin across different treatment groups. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.

Back to article page