Fig. 4

FAM172A modulates biological functions via activation of the PI3K/Akt signaling pathway. (A) Proteomic analysis of differentially expressed proteins following FAM172A modulation. (B, C) Volcano plot (B) and cluster analysis (C) of differentially expressed proteins. (D, E) Western blot analysis of key proteins in the PI3K/Akt pathway under different FAM172A expression conditions. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.