Table 1 Baseline data and comparison of corneal parameters between healthy subjects and glaucoma patients (P-value: comparison between healthy subjects and glaucoma patients overall using: 1 T-Test, 2 Mann–Whitney-U-Test, 3 Chi2-Test; mean value and standard deviation, median and interquartile range 25/75; HPG: high pressure primary open angle glaucoma, NPG: normal pressure primary open angle glaucoma, PEXG: pseudoexfoliative glaucoma, IOP: intraocular pressure, ECD: endothelial cell density, MD: mean deviation, PSD: pattern standard deviation, PGA: prostaglandin analogues, CAI: carbonic anhydrase inhibitors).
From: The corneal thickness profile in different forms of glaucoma
Healthy subjects | Glaucoma (overall) | P | HPG | NPG | PEXG | |
|---|---|---|---|---|---|---|
Baseline data | ||||||
Number | n = 112 | n = 286 | - | n = 161 | n = 76 | n = 49 |
Age (years) | 70.4 ± 8.3 70 (63; 78) | 69.7 ± 9.7 72 (63; 77) | 0.8752 | 69.5 ± 9.4 71 (62; 77) | 67.9 ± 10.3 70.5 (62.3; 76) | 72.9 ± 8.9 75 (67.5; 79.5) |
Male/female | 59/53 | 125/161 | 0.1063 | 74/87 | 27/49 | 24/25 |
Right/left eye | 65/47 | 142/144 | 0.1323 | 82/79 | 38/38 | 22/27 |
IOP (mmHg) | 14.3 ± 3.1 14 (12; 16) | 16.7 ± 5.9 15 (12,7; 19) | 0.0012 | 17.3 ± 5.5 15.8 (13.7; 19.2) | 12.7 ± 2 12.4 (11.2; 13.5) | 21.2 ± 7.4 19.3 (15.8; 25.3) |
ECD (/mm2) | 2489 ± 137 2489 (2392; 2586) | 2146 ± 465 2180 (1862; 2402) | 0.31 | 2137 ± 474 2149 (1851; 2480) | 2335 ± 285 2385 (2202; 2591) | 2094 ± 490 2164 (1806; 2351) |
Pseudo-/phakic | 2/110 | 85/201 | < 0.0013 | 52/109 | 12/64 | 21/28 |
Perimetry and Heidelberg retina tomography | ||||||
MD (dB) | – | -10.9 ± 8.3 -8.6 (-16.2; -4.1) | – | -10.4 ± 8.1 -8.2 (-16.2; -3.6) | -8.7 ± 6.2 -6.9 (-12.6; -3.8) | -16.2 ± 9.7 -14.8 (-25.3; -8.1) |
PSD (dB) | – | 7.8 ± 4.1 8.1 (3.7; 11.1) | – | 7.4 ± 4 7.5 (3.4; 11.1) | 8.5 ± 4,5 8.6 (4.3; 12.3) | 7.9 ± 3.4 8.3 (5; 10.9) |
Rim area (mm2) | - | 1.02 ± 0.42 1 (0.74; 1.27) | – | 1.01 ± 0.39 0.99 (0.75; 1.21) | 1.04 ± 0.37 1.06 (0.77; 1.33) | 1.05 ± 0.58 0.92 (0.67; 1.36) |
Antiglaucomatous local therapy | ||||||
Substances | - | 3.2 ± 1.3 4 (2; 4) | – | 3.4 ± 1.2 4 (3; 4) | 2.6 ± 1.5 3 (1; 4) | 3.6 ± 0.9 4 (3; 4) |
PGA | - | 255 out of 286 (89.2%) | – | 148 out of 161 (91.9%) | 62 out of 76 (81.6%) | 45 out of 49 (91.8%) |
CAI | - | 221 out of 286 (77.3%) | – | 127 out of 161 (78.9%) | 50 out of 76 (65.8%) | 44 out of 49 (89.8%) |
