Table 3 Results of multivariable linear regression for primary corneal outcome parameters to adjust for confounding (The corneal parameters central corneal thickness (CCT), pachy slope, and average peripheral pachymetry value of concentric 5 mm ring around thinnest corneal thickness (PAC 5 mm)) were adjusted for age, sex, lens status, glaucoma subtype, disease duration, intraocular pressure (IOP), number of medications, use of prostaglandin analogues (PGA) and endothelial cell density (ECD). Adjusted regression coefficients (beta), 95% confidence intervals, and exact p-values are reported. Significant results are shown in bold. Since ECD was available in only 137 of 286 patients, a model with (left side, model A) and without (right side, model B) ECD was created.)
From: The corneal thickness profile in different forms of glaucoma
CCT (Beta, 95% CI, p) | Pachy slope (Beta, 95% CI, p) | PAC 5 mm (Beta, 95% CI, p) | CCT (Beta, 95% CI, p) | Pachy slope (Beta, 95% CI, p) | PAC 5 mm (Beta, 95% CI, p) | |
|---|---|---|---|---|---|---|
Model A | Model B | |||||
Age (years) | -0.03 (-0.833; 0.617) 0.769 | -0.01 (-0.535; 0.487) 0.926 | -0.071 (-1.029; 0.496) 0.49 | 0.006 (-0.414; 0.452) 0.931 | -0.098 (-0.418; 0.055) 0.132 | 0.012 (-0.419; 0.51) 0.847 |
Male/female | -0.071 (-16.965; 7.428) 0.44 | 0.099 (-3.962; 13.219) 0.288 | -0.022 (-14.342; 11.3) 0.815 | -0.054 (-11.739; 4.46) 0.377 | 0.079 (-1.543; 7.306) 0.201 | -0.024 (-10.416; 6.942) 0.694 |
Pseudo-/phakic | 0.103 (-6.016; 19.806) 0.292 | 0.117 (-3.627; 14.562) 0.236 | 0.073 (-8.452; 18.693) 0.457 | 0.03 (-7.373; 11.716) 0.655 | 0.088 (-1.752; 8.674) 0.192 | -0.021 (-11.831; 8.624) 0.758 |
Glaucoma subtype | -0.041 (-8.503; 5.386) 0.658 | -0.123 (-8.186; 1.597) 0.185 | -0.001 (-7.33; 7.271) 0.994 | -0.012 (-5.992; 4.925) 0.847 | -0.086 (-5.076; 0.887) 0.168 | 0.006 (-5.565; 6.133) 0.924 |
Disease duration (years) | -0.198 (-1.154; -0.026) 0.041 | -0.095 (-0.596; 0.199) 0.325 | -0.203 (-1.227; -0.041) 0.036 | -0.122 (-0.818; 0.01) 0.056 | -0.017 (-0.256; 0.196) 0.792 | -0.145 (-0.957; -0.07) 0.024 |
IOP (mmHg) | 0.087 (-0.483; 1.418) 0.332 | 0.222 (0.159; 1.498) 0.016 | 0.043 (-0.755; 1.243) 0.629 | 0.211 (0.51; 1.889) 0.001 | 0.157 (0.103; 0.856) 0.013 | 0.184 (0.374; 1.852) 0.003 |
Number of medications | 0.148 (-2.732; 11.394) 0.227 | 0.038 (-4.207; 5.743) 0.76 | 0.132 (-3.391; 11.459) 0.284 | 0.03 (-3.312; 4.92) 0.701 | -0.024 (-2.602; 1.895) 0.757 | 0.003 (-4.311; 4.511) 0.964 |
PGA exposure | -0.27 (-59.41; -3.259) 0.029 | -0.055 (-24.213; 15.34) 0.658 | -0.226 (-56.927; 2.102) 0.068 | -0.151 (-33.026; -0.816) 0.04 | -0.06 (-12.419; 5.174) 0.418 | -0.127 (-32.422; 2.093) 0.085 |
ECD (/mm2) | 0.125 (− 0.004; 0.023) 0.185 | 0.045 (− 0.007; 0.012) 0.635 | 0.125 (− 0.005; 0.024) 0.187 | – | – | – |
