Table 1 Characteristics and main results of included studies (n = 88).

From: Global performance of machine learning models to predict all-cause mortality: systematic review and meta-analysis

Author, year and title

Location

Sample characteristics

Predictor variables

Outcome

Models

AUC results and best performing model

Banerjee et al., 202149

United Kingdom

1706 patients with schizophrenia, average age not specified

Antidepressants, second-generation antipsychotics, alcohol/substance abuse, delirium, dementia, cardiovascular disease, diabetes, other physical and mental health issues, social factors like family support

All-cause mortality in schizophrenia patients

Logistic regression, random forests, deep learning models

0.80

Random forest model

Meredith et al., 200250

United States

76,871 incidents, 72,827 survivors, 4044 deceased

Scores based on AIS and ICD-9, including ISS, NISS, APS, maxAIS and their mapped ICD to AIS versions, and the ICD-9 based ICISS score

All-cause mortality

Scoring algorithms based on AIS and ICD, logistic regression used for calibration

0.89

ICISS

Li et al., 202328

China

10,311 patients with heart failure

66 predictors including demographics, pre-existing conditions, treatments received, and other clinical and laboratory details

All-cause mortality within 30 days, 180 days, 365 days, and after 365 days

Deep Learning System based on Multi-head Self-attention Mechanism (DLS-MSM)

0.75

DLS-MSM

Barsasella et al., 202227

Taiwan

58,618 patients, including 25,868 with T2DM, 32,750 with HTN, and 6,419 with both conditions, average age 75.12 ± 13.65 years

67 predictor variables including hospital cost, vital signs and symptoms, comorbidities, demographic characteristics

All-cause mortality

Logistic Regression, Ridge Classifier, Random Forest, K-Neighbors Classifier, Bagging Classifier, Gradient Boosting Classifier

0.97

Logistic Regression

Wang Y. et al., 202151

China

1,200 patients with ESRD undergoing HD, using 36 continuous HD sessions to predict 90-day mortality

64 variables related to hemodialysis sessions, including patient blood pressure recorded multiple times per session

Mortality within 90/180/365 days

LSTM Autoencoder, Logistic Regression, Support Vector Machine, Random Forest, LSTM Classifier, Isolation Forest, Stacked Autoencoder

0.73

LSTM

Díez-Sanmartín et al., 202325

Spain

44,663 adults on kidney transplant waiting list, dialysis < 15 years

Sociodemographic factors (e.g., age, gender, etc.)

Mortality on kidney transplant waiting list

XGBoost, K-Means, Agglomerative Clustering

0.99

XGBoost

Xiong J et al., 202310

China

579 tumor samples from endometrial cancer patients

PCD-related genes

All-cause mortality

LASSO

0.92

LASSO

Lin et al., 201952

Taiwan

48,153 ESRD patients aged ≥ 65 years

Age, sex, urbanization level, occupation, comorbidities (including diabetes, hypertension, etc.)

One-year all-cause mortality

Random Forest, Artificial Neural Networks

0.68

Artificial Neural Networks

Liu et al., 202253

Taiwan, Japan

28,745 patients, 20–60 years old

ECG recordings, AI-predicted LVH

All-cause mortality

Deep learning

0.74

Deep learning

Shi et al., 201254

Taiwan

22,926 patients undergoing surgery for hepatocellular carcinoma

Initial clinical data, surgeon volume, hospital volume

5-year mortality

Artificial Neural Networks and Logistic Regression

0.89

Artificial Neural Networks

L. Shi, X.C. Wang, Y.S. Wang, 201355

China

2,150 elderly patients with intertrochanteric fractures, mean age 81.6 years

Age, gender, nursing home, New Mobility Score, dementia or cognitive impairment, diabetes, cancer, cardiac disease

1-year mortality

Artificial Neural Networks and Logistic Regression

0.87

Artificial Neural Networks

Puddu and Menotti, 201256

Italy

1591 men aged 40–59 years, enrolled in 1960 from rural communities in Crevalcore and Montegiorgio with cardiovascular disease

Age, father life status, mother life status, family history of CVD, job-related physical activity, smoking, BMI, arm circumference, blood pressure, heart rate, forced expiratory volume, serum cholesterol, corneal arcus, diagnoses of CVD, cancer, diabetes, minor ECG abnormalities

45-year all-cause mortality

Cox proportional hazards models, Multilayer Perceptron, AND Neural Networks

0.842

Neural Networks

Harris et al., 201957

United States

107,792 patients undergoing nonemergency primary total hip arthroplasties (THAs) and total knee arthroplasties (TKAs) from the ACS-NSQIP dataset 2013–2014

Demographic and clinical variables such as American Society of Anesthesiologists classification, comorbidities, age, and gender

30-day mortality

LASSO Regression

0.73

LASSO

Takahama et al., 20238

Japan

987 heart failure patients, hospitalized, data from 2013 to 2016

15 variables including troponin levels, blood pressure, BMI, hematocrit, BNP levels, CRP, LDL cholesterol, white blood cell count, diastolic blood pressure, creatinine levels, BUN, LVEF

One-year mortality in heart failure patients

Light Gradient Boosting Machine (LightGBM)

0.87

LightGBM

Arostegui et al., 20189

Spain

1,945 patients with colon cancer who had surgery

Residual tumor, ASA Physical Status, pathologic tumor staging, Charlson Comorbidity Index, intraoperative complications, adjuvant chemotherapy, tumor recurrence

1-year mortality post-surgery

Random Forest, Genetic Algorithms, Classification and Regression Trees (CART)

0.90

Multimodels

Jing et al., 202258

United States

124,360 veterans aged > 50; 93.9% male; mean age 68.2 years

924 predictors including demographics, vital signs, medication classes, disease diagnoses, laboratory results, healthcare utilization

10-year all-cause mortality

Gradient Boosting, Random Forest, Neural Networks, SuperLearner ensemble, LASSO

0.84

Gradient Boosting

Tedesco et al., 202129

Sweden

2,291 healthy older adults aged 70

Anthropometric variables, physical and lab exams, questionnaires, lifestyle, wearable data

All-cause mortality

Logistic Regression, Decision Tree, Random Forest, AdaBoost

0.51

AdaBoost

Sakr et al., 201759

United States

34,212 patients, age 54 ± 13 years, 55% male

Fitness data from exercise treadmill stress testing, demographic and clinical variables

All-cause mortality

Decision Tree, Support Vector Machine, Artificial Neural Networks, Naïve Bayesian Classifier, Bayesian Network, K-Nearest Neighbor, Random Forest

0.97

Random Forest

Jones et al., 202160

United States

297,498 encounters, median age 68 years, 95% male, including demographics, vital signs, and 21 laboratory values

Demographic characteristics, 38 comorbid conditions, five vital signs, 21 laboratory values, utilizing PSI variables and excluding mental status and chest imaging

30-day all-cause mortality

Logistic regression, spline models, Extreme Gradient Boosting (XGBoost) incorporating various subsets of predictor variables

0.88

XGBoost

Singh et al., 202261

United States

4,735 patients referred for PET between 2010–2018, median follow-up of 4.15 years

Polar maps of stress and rest perfusion, myocardial blood flow, myocardial flow reserve, spill-over fraction, cardiac volumes, singular indices, sex

All-cause mortality

Deep Learning

0.82

Deep Learning

Lu et al., 201962

United States

PLCO: 10,464 participants, mean age 62.4; NLST: 5,493 participants, mean age 61.7; both included smokers and nonsmokers aged 55–74 years

Chest radiographs

All-cause mortality

Convolutional Neural Network

0.75 and 0.68

Convolutional Neural Network

Siegersma et al., 202226

Netherlands

1,136,113 ECGs from 249,262 individuals, ages 18–85, from UMC Utrecht

12-lead resting ECGs

All-cause mortality

Deep Neural Network

0.96

Deep Neural Network

Ulloa Cerna et al., 202163

United States

34,362 individuals, 812,278 echocardiographic videos

Raw pixel data from echocardiographic videos

All-cause mortality

Convolutional Neural Network

0.84

Convolutional Neural Network

Wang et al., 202164

United States

Patients aged 50 + from a large healthcare system with documented cognitive decline

Clinical notes from EHRs

All-cause mortality

Deep Learning

0.94

Deep Learning

Mohammad et al., 202265

Sweden

139,288 patients admitted for myocardial infarction from the SWEDEHEART registry

Demographic info, medical history, hospital characteristics, lab results

1-year all-cause mortality

Artificial Neural Network

0.85

Artificial Neural Network

Valsaraj et al., 202366

India and Canada

6,083 echos from Taiwan; 997 echos from Alberta, Canada

Echocardiographic data, demographic and clinical data

All-cause mortality (1-year, 3-year, 5-year)

ResNet, CatBoost

0.92

CatBoost

Li et al., 202367

China

Two cohorts: CHNS (8,355 adults > 18 years) and CHARLS (12,711 adults > 45 years)

159 variables from demographics, family, community, socioeconomic status, lifestyle, health conditions, etc

All-cause mortality

Cox Regression, LASSO, Survival Tree, Random Survival Forest, Conditional Inference Forest, glmBoost, Gradient Boosting

0.86

Random Survival Forest

Zhou et al., 202268

Hong Kong

2,560 patients with pulmonary hypertension; median age 63.4 years

Age, average readmission interval, cumulative hospital stay, anti-hypertensive drugs, total bilirubin

All-cause mortality

Random Survival Forest

0.95

Random Survival Forest

Giang et al., 202169

Sweden

71,941 patients with congenital heart disease, mean follow-up time of 16.47 years

Congenital heart disease classifications, comorbidities

All-cause mortality

Neural Networks and Logistic Regression

0.92

Neural Networks

Forte et al., 202170

Netherlands

8,241 patients undergoing valve or CABG operations, mean follow-up of 5 years

Peri-operative clinical parameters

5-year mortality

Super Learner, GLM, XGBoost

0.81

Super Learner

Bergquist et al., 202124

United States

1,264,000 patients

Various clinical predictors

All-cause mortality

Boosted methods, logistic regression, neural networks

0.95

LightGBM

Hernesniemi et al., 201971

Finland

9,066 patients with acute coronary syndrome

Extensive clinical data, GRACE score

Six-month mortality

Logistic regression and XGBoost

0.89

XGBoost

Heyman et al., 202123

Sweden

148 patients discharged from ED, ages 23–106, general ED population

Age, sex, comorbidity score, arrival mode, discharge time, triage priority, imaging during visit

All-cause mortality within 30 days

Logistic Regression, Random Forest, Support Vector Machine

0.95

Logistic Regression

Qiu et al., 202272

United States

47,261 participants, ages across various ranges (data from NHANES 1999–2014)

Demographic, laboratory, examination, questionnaire predictors

All-cause mortality

Gradient Boosted Trees and TreeExplainer

0.92

Gradient Boosting

Niedziela et al., 202173

Poland

17,793 patients treated with primary percutaneous coronary intervention for anterior STEMI

Age, gender, blood pressure, heart rate, Killip class, medical history, in-hospital treatment

6-month all-cause mortality

Logistic Regression, Neural Network

0.81

Neural Network

Mostafaei et al., 202374

Sweden

28,023 dementia-diagnosed patients from the Swedish Registry for Cognitive/Dementia Disorders (SveDem). Median follow-up time was 1053 days for surviving and 1125 days for deceased patients

Age, sex, BMI, MMSE score, dementia type, comorbidities, medications

All-cause mortality

Logistic Regression, Support Vector Machine, Neural Networks

0.74

Support Vector Machine

Cui et al., 202275

United States

19,887 lung cancer patients with bone metastases

Age, primary site, histology, race, sex, T stage, N stage, brain metastasis, liver metastasis, cancer-directed surgery, radiation, chemotherapy

3-month mortality

Logistic Regression, XGBoosting Machine, Random Forest, Neural Network, Gradient Boosting Machine, Decision Tree

0.82

Gradient Boosting Machine

Parikh et al., 201976

United States

26,525 adult patients who had outpatient oncology or hematology/oncology encounters at a large academic cancer center and affiliated community practices

Demographic variables, Elixhauser comorbidities, laboratory data

180-day mortality

Logistic Regression, Random Forest, Gradient Boosting

0.88

Random Forest

Tong et al., 202177

China

578 liver cancer patients undergoing RFA

Platelet count (PLT), Alpha-fetoprotein (AFP), age, tumor size, total bilirubin

All-cause mortality

Logistic Regression, DecisionTree, gbm, Gradient Boosting, Forest

0.74

Gradient Boosting model

de Capretz et al., 202378

Sweden

9519 ED chest pain patients, avg. age 59, 47.3% female

Age, sex, ECG, hs-cTnT, glucose, creatinine, hemoglobin

AMI or all-cause death within 30 days

Convolutional neural network, ANN, Logistic Regression

0.94

Convolutional neural network

Tian et al., 202379

China

424 patients with HFmrEF, median follow-up of 1008 days

Age, NYHA class, LVEF, eGFR, NT-proBNP, various lab results

All-cause mortality

XGBoost, Random Forest, SVM

0.92

XGBoost

Mamprin et al., 202180

Netherlands

1,931 TAVI procedures (1,300 at AMC and 631 at CZE)

Clinical predictors including age, health history, and procedural data

One-year mortality

Logistic Regression, Random Forest, CatBoost

0.68

CatBoost

Motwani et al., 201681

Multiple countries

10,030 patients with suspected CAD, 5-year follow-up

25 clinical and 44 CCTA parameters

All-cause mortality within 5 years

Boosted ensemble

0.79

Boosted ensemble

Santos et al., 201982

Brazil

2,808 elderly participants, mean age not specified, general population

37 demographic, socioeconomic, and health profile variables

All-cause mortality within five years

Logistic regression, neural networks, gradient boosted trees, random forest

0.80

Neural Network

Feng et al., 202383

China

8,943 participants, mean age 61.1 years, 79.6% male, all with three-vessel coronary artery disease

18 selected predictors including demographics, medical history, blood tests, and cardiac function assessments

All-cause mortality over 4 years

Random forest

0.81

Random Forest

Yu et al., 202284

China

7,368 patients, age older than 18, post-cardiac surgery including CABG, valvular operations

25 selected predictors including demographics, comorbidities, vital signs, and lab results

4-year all-cause mortality

Logistic regression, neural networks, naïve bayes, gradient boosting, adapting boosting, random forest, bagged trees, extreme gradient boosting

0.80

Adapting boosting

Tamminen et al., 202185

Finland

2,853 unselected prehospital patients encountered in June 2015

NEWS parameters, blood glucose

30-day mortality

Random Forest

0.76

Random Forest

Xu et al., 202386

United States

630 patients with advanced cancer, mean age 59.1 years, 56.19% female

Demographics, clinical data, patient-reported outcomes (PROs) from the Edmonton Symptom Assessment System (ESAS)

180-day mortality

GLM with elastic net, XGBoost, SVM, Neural Network

0.69

XGBoost

Katsiferis et al., 202387

Denmark

48,944 Danish citizens aged 65 and older, spousal bereavement

Age, sex, healthcare expenditures, sociodemographics

All-cause mortality

XGBoost

0.81

XGBoost

Kanda et al., 202288

Japan

24,949 adults with hyperkalemia, multifactorial conditions, aged ≥ 18

Clinical data, lab results, prescription history

All-cause mortality

XGBoost and Logistic Regression

0.82

XGBoost

Lu et al., 202189

Australia

68,889 patients, mean age 76 years, 54% female

Age, sex, medication history, disease history

All-cause mortality

Gradient Boosting Machine, Multi-Layer Neural Network, Support Vector Machine

0.75

Gradient Boosting

Scrutinio et al., 202090

Italy

1,207 patients with severe stroke, average follow-up 988 days, 15.7% 3-year mortality rate

Age, comorbidities (e.g., diabetes, CAD), functional measures

3-year mortality

Random Forest, Logistic Regression

0.93

Random Forest

Li et al., 202091

China

1,244 patients, mean age 63.8, 78.4% male, 75.18% received reperfusion therapy

Comprehensive clinical dataset including demographics and treatment details

1-year mortality after anterior STEMI

GaussianNB, Logistic Regression, KNN, Decision Tree, Random Forest, XGBoost

0.94

XGBoost

Guo et al., 202292

China

751 patients diagnosed with spontaneous intracerebral hemorrhage at West China Hospital

Clinical presentations, laboratory data (e.g., monocyte and lymphocyte levels), radiographic data, Glasgow Coma Scale, hematoma volume, location, age

90-day mortality

Logistic Regression, Category Boosting, Support Vector Machine, Random Forest, Extreme Gradient Boosting

0.84

Logistic Regression

Wang et al., 202311

United States

1229 patients from the MIMIC-IV database, including critical pulmonary embolism patients with or without septic or other cardiopulmonary complications

Age, gender, DVT, VTE history, hematocrit, hemoglobin, anion gap, heart rate, blood pressure, respiratory rate, congestive heart failure, hypertension, atrial fibrillation, vasopressor

All-cause mortality within 30 days

Logistic Regression and XGBoost

0.82

XGBoost

Li et al., 202393

China

451 older patients with CAD, IGT, and DM from a hospital cohort, split into a training group (308) and a validation group (143). Median age 86 years. Majority were males

Demographics, comorbidities (e.g., CHF, DM, hypertension), laboratory tests (e.g., glucose, NT-proBNP), and medications used during hospitalization (e.g., statins, beta blockers)

All-cause mortality

Logistic Regression, Gradient Boosting, Random Forest, Decision Tree

0.84

Gradient Boosting

Asrian et al., 202494

United States

3751 hip fracture patients from the MIMIC-IV database. Includes demographics like age and basic lab tests. Average age was 73

Age, glucose, red blood cell distribution width, mean corpuscular hemoglobin concentration, white blood cells, urea nitrogen, prothrombin time, platelet count, calcium levels, and partial thromboplastin time

1-, 5-, and 10-year mortality

LightGBM, Random Forest, Logistic Regression

0.79

LightGBM

Ivanics et al., 202395

Canada, United Kingdom, United States

Adults who underwent primary liver transplants from Jan 2008 to Dec 2018: Canada (n = 1214), UK (n = 5287), US (n = 59,558)

Harmonized pre-transplant variables like recipient BMI, donor age, MELD score, etc., across three national registries

90-day mortality

LASSO, Ridge, ElasticNET, LightGBM

0.74

Ridge

Behnoush et al., 202396

Iran

8,493 hypertensive patients undergoing CABG, mean age 68.27 years, 63.86% male, 46.84% with diabetes, 38.61% with a family history of CAD

Age, total ventilation hours, ejection fraction, hemoglobin, total cholesterol, LDL-C, HDL-C, triglycerides, fasting blood glucose, creatinine, BMI, and several perioperative factors like ICU hours and cardiopulmonary pump use

1-year mortality

Logistic Regression, Extreme Gradient Boosting, Naïve Bayes, Random Forest, Artificial Neural Network

0.82

Logistic Regression

Kampaktsis et al., 202397

United States

1033 recipients (median age 34 years, 61% male) of isolated heart transplants analyzed from the UNOS database, 2000–2020

Variables included recipient, donor, procedural characteristics, post-transplant predictors, selected using SHapley Additive exPlanations (SHAP)

1-year mortality

CatBoost

0.80

CatBoost

Lin et al., 202098

Taiwan

1,903 patients from Wan Fang Hospital and Taipei Medical University Hospital, diagnosed with chronic liver diseases such as cirrhosis and hepatic coma

Variables included clinical scores (e.g., MELD score), laboratory data (e.g., bilirubin, creatinine), and demographic data

All-cause mortality

Random Forest, Adaptive Boosting, other machine learning models

0.85

Random Forest

Lin et al., 202399

United States

63,215 asymptomatic patients from four centers, median age 54, 68% male, median follow-up 12.6 years

Age, sex, race, CAD risk factors, CAC score, CAC density, number of calcified vessels

10-year all-cause mortality

XGBoost

0.82

XGBoost

Liu et al., 2022100

China

340 patients with sepsis-induced CRS at Shanghai Tongji Hospital, aged ≥ 18, data from 2015–2020

Age, SOFA score, myoglobin levels, vasopressor use, mechanical ventilation

1-year mortality

Random Forest, Support Vector Machine, Gradient Boosted Decision Tree

0.85

Random Forest

Forssten et al., 2021101

Sweden

124,707 traumatic hip fracture cases, aged 18 or older, between 2008 and 2017

Age, sex, ASA classification, CCI, RCRI, various comorbidities, type of fracture, surgical procedure

1-year postoperative mortality

Logistic Regression, Naive Bayes, Support Vector Machine, Random Forest

0.74

Random Forest

Alimbayev et al., 2023102

Kazakhstan

472,950 patients diagnosed with diabetes mellitus, collected between 2014–2019 from the Unified National Electronic Health System of Kazakhstan

Age, duration of diabetes, hypertension, sex, and other comorbidities like coronary heart disease and cerebrovascular accident

1-year mortality

Gaussian Naïve Bayes, K-nearest neighbors, Logistic Regression, Random Forest, AdaBoost, Gradient Boosting, XGBoost, Linear Discriminant Analysis, Perceptron

0.80

XGBoost

El-Bouri et al., 2023103

United Kingdom

2,183 venous thromboembolism patients; 1235 pulmonary embolism cases; mean age 69 years

Neutrophils, white blood cell counts, C-reactive protein, haemoglobin, age, O2 saturation, heart rate, blood pressure

30-day, 90-day, and 365-day mortality

Random Forest, XGBoost, logistic regression

0.73

Random Forest

Park et al., 2022104

South Korea

4,312 patients with acute heart failure, median age 73, 55% male, median left ventricular ejection fraction 38%

19 clinical predictors (e.g., age, sex, blood pressure) and 8 echocardiographic parameters (e.g., LV ejection fraction)

All-cause mortality at 3 years

CoxBoost

0.76

CoxBoost

Penso et al., 2021105

Italy

471 patients with severe AS, undergoing TAVI, median age 81

83 pre-TAVI clinical and echocardiographic variables

All-cause mortality at 5 years

Random forest, XGBoost, Multilayer perceptron, Logistic regression

0.79

Multilayer perceptron

Guo et al., 2021106

United States

34,575 patients with liver cirrhosis

41 health variables including demographic and laboratory data

All-cause mortality at 90, 180, and 365 days

Deep Neural Networks (DNN), Random Forest (RF), Logistic Regression (LR)

0.86

Random Forest

Abedi et al., 2021107

United States

7,144 patients post-stroke

37 predictors including demographics, medical history, laboratory data

All-cause mortality within 1, 3, 6, 12, 18, and 24 months

Logistic Regression, Extreme Gradient Boosting, Random Forest

0.82

Random Forest

Zhou et al., 2023108

China

706 patients, median age 66, 57% male, diagnosed with mitral regurgitation

Age, blood pressure, P-wave duration, lab values (e.g., albumin, creatinine), echocardiographic measurements (e.g., LVEF, LADs)

All-cause mortality

Gradient Boosting Machine, Logistic Regression, Decision Tree, Random Forest, Support Vector Machine, Artificial Neural Networks

0.80

Gradient Boosting Machine

Rauf et al., 2023109

Pakistan

2,184 patients with mitral stenosis and atrial flutter, 81.85% females, median age 65

Mitral valve area, right ventricular systolic pressure, pulmonary artery pressure, left ventricular ejection fraction, NYHA class, surgery

All-cause mortality

Gradient Boosting Machine, Decision Tree, Support Vector Machine, Random Forest, Artificial Neural Network

0.84

Gradient Boosting Machine

Shi et al., 2022110

China, United Kingdom

2,846 patients with acute pancreatitis, median age 46 years

Demographic info, lab tests on admission (WBC, creatinine, etc.), clinical severity scores (APACHE II, SOFA)

Mortality

Random Forest

0.89

Ranfom Forest

Zhou et al., 2021111

China

381 heart transplant recipients, average age 43.8 years

Albumin, recipient age, left atrium diameter, red blood cells, hemoglobin, lymphocyte%, smoking history, use of rhBNP, Levosimendan, hypertension, cardiac surgery history, malignancy, endotracheal intubation history

1-year mortality

Logistic Regression, Support Vector Machine, Random Forest, Extreme Gradient Boosting, Adaptive Boosting, Gradient Boosting Machine, Artificial Neural Network

0.80

Random Forest

Lee et al., 2021112

South Korea

22,182 AMI patients, mean age 64 years, 71.8% male

Demographics, clinical predictors, lab results, history of heart disease, interventions, medications

1-year all-cause mortality

Decision Trees, Logistic Regressions, Deepnets, Random Forest

0.92

Random Forest

Tran et al., 2023113

France

534 stage 4–5 CKD patients, median age 72 years, 55% male

Age, ESA usage, cardiovascular history, smoking status, vitamin D levels, PTH levels, ferritin levels

2-year all-cause mortality

Bayesian Network, Deep Learning, Logistic Regression, Random Forest

0.81

Bayesian Network

Raghunath et al., 2020114

United States

253,397 patients with 1,169,662 12-lead resting ECGs from a large regional health system, 99,371 events occurred over a 34-year period

12-lead ECG voltage–time traces, age, sex

1-year all-cause mortality

Deep Neural Network

0.88

Deep Neural Network

Kawano et al., 2022115

Japan

116,749 participants from health checkups; age, sex, and other health data collected

Age, sex, smoking, AST levels, alcohol consumption, and other health checkup data

5-year all-cause mortality

Gradient Boosting Decision Tree (XGBoost), Neural Network, Logistic Regression

0.81

XGBoost

Weng et al., 2019116

United Kingdom

502,628 participants aged 40–69, recruited from the general population

60 predictor variables including demographics, lifestyle factors, and clinical measures

Premature all-cause mortality

Deep Learning, Random Forest, Cox regression

0.79

Deep Learning

Zhou et al., 2021117

China

1,241 patients with end-stage renal disease (ESRD) on peritoneal dialysis; age range 18 + , routine follow-up for 12 + months

Age, sex, chronic heart disease, diabetes, malignancy, systolic and diastolic blood pressure, cholesterol levels, serum albumin, hemoglobin, blood urea nitrogen, serum creatinine

Premature all-cause mortality

Logistic Regression, Classic Artificial Neural Network, Mixed Artificial Neural Network

0.79

Artificial Neural Network

Huang et al., 2017118

Taiwan, China

3,632 breast cancer patients from a retrospective cohort study, underwent surgery between 1996 and 2010

Age, Charlson Comorbidity Index (CCI), chemotherapy, radiotherapy, hormone therapy, surgery volumes of hospital and surgeon

5-year mortality after breast cancer surgery

Artificial Neural Network, Multiple Logistic Regression, Cox Regression

0.72

Artificial Neural Network

Sheng et al., 2020119

China

5,351 patients in training cohort and 5,828 in testing cohort from 97 renal centers, all new hemodialysis patients

Demographic info, disease diagnoses, comorbidities, and lab results collected at dialysis start and 0–3 months post-start

First-year all-cause mortality

XGBoost, Random Forest, and Logistic Regression

0.85

XGBoost

Zachariah et al., 2022120

United States

2,041 patients with advanced cancer, median age 62.6 years

Demographic data, lab results, diagnostic codes, past medical history

3-month mortality

XGBoost

0.81

XGBoost

Unterhuber et al., 2021121

Germany, Italy

1,998 patients from LIFE-Heart Study (Germany), 772 from PLIC Study (Italy), aged 41–85, at increased cardiovascular risk

92 plasma proteins measured, alongside clinical risk scores like SCORE and Framingham, and other clinical data

All-cause mortality

XGBoost, Neural Network

0.94

Neural Network

Wu et al., 2024122

China

11,894 patients aged ≥ 65 years who underwent non-cardiac surgery across 20 tertiary hospitals

Preoperative risk factors including medical history (stroke, chronic diseases), laboratory data (mononuclear cell ratio, total cholesterol), and preoperative assessments

6-month mortality

Random Forests, Support Vector Machine, Decision Tree, Naive Bayes

0.97

Random Forest

Hwangbo et al., 2022123

South Korea

19,435 patients assessed from the IST-1 dataset, with 8,787 included after exclusions for various reasons such as treatment type and missing data

18 variables including age, sex, level of consciousness, underlying conditions, and imaging findings

6-month all-cause mortality

Stacking Ensemble, Extreme Gradient Boosting, KNN, SVM, Naive Bayes, Random Forest, Logistic Regression

0.78

Stacking Ensemble

Ross et al., 2016124

United States

1,755 patients undergoing elective coronary angiography at Stanford University Medical Center or Mount Sinai Medical Center from 2004 to 2008

Demographics, clinical comorbidities, medications, lab tests, physical exam variables, socioeconomic variables, genomic markers

All-cause mortality

Elastic Net, Random Forest

0.76

Random Forest

Wang et al., 2019125

United States

40,711 completed cases from the Cardiovascular Disease Life Risk Pooling Project, which includes various demographics, physiological test results, medication status, socio-behavioral factors, and mortality indicators

Demographics, physiological tests, medication status, socio-behavioral factors

All-cause mortality

Naïve Bayes, Logistic Regression, Support Vector Machine, Random Forest

0.89

Random Forest

  1. Detailed overview of study characteristics including author, location, sample size, predictor variables, outcomes, machine learning models used, and AUC results for each of the 88 studies included in the systematic review.