Table 2 Differentially expressed proteins in mitochondria of healthy fibroblasts in hypoxia

From: Mitochondrial proteomics reveals reductive metabolism dependent on glutamine in fibroblasts of idiopathic pulmonary fibrosis under hypoxia

Symbol (UniProtKB)

Description

Unique Peptides

log2 Ratio

P value

Max fold chang

ACSL3

Fatty acid CoA ligase

1

2.31

0.004

4.81

PHB2

Prohibitin

1

2.11

0.016

3.52

ACAD8

Isobutyryl-CoA dehydrogenase mitochondrial

1

1.97

0.003

1.57

VDAC1

Voltage-dependent anion-selective channel protein 1

4

1.23

0.017

2.69

ATP13A2

Isoform B of Polyamine-transporting ATPase 13A2

1

0.95

0.011

1.04

LGALS3

Galectin-3

6

0.88

0.014

1.97

ACSM1

Acyl-coenzyme A synthetase ACSM1 mitochondrial

1

0.74

0.003

1.60

ACAD10

Acyl-CoA dehydrogenase family member 10

3

− 0.72

0.046

1.52

MYG1

MYG1 exonuclease

1

− 0.80

0.013

1.53

POR

NADPH-cytochrome P450 reductase

1

− 0.92

0.002

1.48

GSTK1

Glutathione S-transferase kappa 1

4

− 1.23

0.018

3.00

GRK6

G protein-coupled receptor kinase

1

− 2.14

0.033

3.73

  1. The first column shows the UniProtKB symbol, followed by protein description, unique peptides, log ratio, ANOVA p-value, log 2 ratio, and maximum fold change of mitochondrial proteins in hypoxic control fibroblasts. Negative ANOVA p-values indicate a decrease in protein levels compared to normoxia. A log 2 ratio of + 1 indicates a doubling of protein levels, while -1 indicates halved levels under the experimental condition
Back to article page