Table 3 Differentially expressed proteins in mitochondria of IPF fibroblasts in hypoxia

From: Mitochondrial proteomics reveals reductive metabolism dependent on glutamine in fibroblasts of idiopathic pulmonary fibrosis under hypoxia

Symbol (UniProtKB)

Description

Unique peptides

log2 ratio

P value

Max fold change

GLS

Glutaminase kidney isoform mitochondrial

3

1.53

0.024

2.66

SLC25A3

Phosphate carrier protein mitochondrial

4

0.79

0.015

1.46

MRPL12

39S ribosomal protein L12 mitochondrial

1

− 0.73

0.031

1.52

RAP1GDS1

Isoform 4 of Rap1 GTPase-GDP dissociation stimulator 1

1

− 1.17

0.020

1.48

SRBD1

S1 RNA-binding domain-containing protein 1

1

− 1.26

0.021

5.29

PSAP

Prosaposin

2

− 2.00

0.025

1.08

  1. The first column shows the UniProtKB symbol, followed by protein description, unique peptides, log ratio, ANOVA p-value, log 2 ratio, and maximum fold change of mitochondrial proteins in IPF hypoxic fibroblasts. Negative ANOVA p-values indicate a decrease in protein levels compared to normoxia. A log 2 ratio of + 1 indicates a doubling of protein levels, while -1 indicates halved levels under the experimental condition.
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