Fig. 6
From: Temporary effects of random positioning on the function and plasticity of proliferating monocytes
Comparison of RPM effects in subpopulations of (a) proliferating leukemic THP-1 monocytes after 3 days and (b) non-proliferating monocytes derived from the blood. Only the proliferating cells respond to random positioning, which indicates mechanosensitivity in the progressing cell cycle. Reduced mechanosensitivity in circulating blood-derived monocytes not only indicates resistance to physiomechanical influences (blood pressure, pulse, body movements), but also suggests that microgravity should have no influence on this cell type in astronauts (small image). (c) Early and late effects of RPM cell culture on THP-1 cells. The late effects of RPM cell culture show similarities to dedifferentiation of THP-1 monocytes. LPS, lipopolysaccharide; PMA, phorbol 12-myristate 13-acetate. Parts of the figure were drawn using pictures from Biorender.com and Servier Medical Art.
