Fig. 6
The 3D cell culture models sensitivity to anti-PARP cancer treatments. Cells were seeded at optimal selected conditions of cell and matrix concentrations (SUM1315: 1,000 cells per well/2% matrix, SK-OV-3: 1,000 cells per well/2% matrix and MCF-10A: 5,000 cells per well/1% matrix). (1) Spheroid size and (2) Metabolic activity were measured after 10 days of exposure to three anti-PARP treatments: (a) Olaparib, (b) Rucaparib and (c) Niraparib, at three concentrations of 1 µM, 10 µM and 50 µM. Data represent means ± SD, where p < 0.05 (*) p < 0.01 (**), p < 0.001 (***); p < 0.0001 (****), according to Kruskal-Wallis test.
