Table 2 Changes in BMI (g/cm2) before and after treatments in the control, obese, α-LA, Caf-CNPs and α-LA + Caf-CNPs.

From: The effect of alpha lipoic acid and caffeine loaded into chitosan nanoparticles on the hypothalamic amino acid neurotransmitters in a rat model of obesity

Animal groups

20 weeks

BMI g/cm2

Daily treatment for 4 weeks

BMI g/cm2

Lean control rats

Fed a standard diet

0.514

Saline (0.9%)

0.54

Control obese rats

Fed HFD

0.73

Saline (0.9%)

0.77

Obese rats treated with Rat α-LA

Fed HFD

0.78

α-LA (100 mg/kg)

0.638

Obese rats treated with Rat Caf-CNPs

Fed HFD

0.79

Caf-CNPs (20 mg/kg)

0.649

Obese rats treated with α-L A+ Caf-CNPs

Fed HFD

0.791

α-L A + Caf-CNPs

0.623