Fig. 4

Boxplots and receiver operating characteristic (ROC) curve of differentially expressed autophagy-related genes (DE-ARGs) from the training set (the merged dataset of GSE87466 and GSE92415) and test sets (GSE38713 and GSE75214). (a) Boxplot of DE-ARG (PEA15, SERPINA1, CASP1, and CASP4) expression levels in the training set, comparing the UC group (blue) and the normal group (red). (b) Boxplot of DE-ARG (PEA15, SERPINA1, CASP1, and CASP4) expression levels in the validation set GSE38713. (c) Boxplot of DE-ARG (PEA15, SERPINA1, CASP1, and CASP4) expression levels in the validation set GSE75214. (d) ROC curve illustrating the classification performance of the four DE-ARGs in the training set. (e) ROC curve illustrating the classification performance of the four DE-ARGs in the validation set GSE38713 and GSE75214, where a larger area under the curve (AUC) indicates better predictive performance and discriminative ability of the gene.