Table 1. Characteristics of the study cohorts.
Variable | Training cohort (N = 914) | Internal validation cohort (N = 393) | External validation cohort (N = 61) |
|---|---|---|---|
Gender | |||
Female | 910(99.56) | 390(99.24) | 61(100) |
Male | 4(0.44) | 3(0.76) | NA |
Age | |||
≤35 years | 41(4.49) | 23(5.85) | 2(3.28) |
36–45 years | 156(17.07) | 66(16.79) | 12(19.67) |
46–59 years | 469(51.31) | 190(48.35) | 23(37.70) |
≥60 years | 248(27.13) | 114(29.01) | 24(39.34) |
Tumor size | |||
T1 | 891(97.48) | 382(97.20) | 27(44.26) |
T2 | 18(1.97) | 9(2.29) | 33(54.10) |
T3 | 5(0.55) | 2(0.51) | 1(1.64) |
Lymphatic metastasis | |||
Positive | 427(46.72) | 178(45.29) | 26(42.62) |
Negative | 487(53.28) | 215(54.71) | 35(57.38) |
Pathological type | |||
Invasive Ductal Carcinoma | 829(90.70) | 366(93.13) | 52(85.25) |
Invasive Lobular Carcinoma | 27(2.95) | 11(2.80) | 2(3.28) |
Other | 58(6.35) | 16(4.07) | 7(11.48) |
Histological grading | |||
I grade | 33(3.61) | 14(3.56) | 2(3.28) |
II grade | 378(41.36) | 169(43.00) | 24(39.34) |
III grade | 503(55.03) | 210(53.44) | 35(57.38) |
Molecular subtyping | |||
Luminal A | 93(10.18) | 67(17.05) | 5(8.20) |
Luminal B(HER2 negative) | 443(48.47) | 163(41.48) | 38(62.30) |
Luminal B(HER2 positive) | 121(13.24) | 51(12.98) | 6(9.84) |
HER2 positive | 105(11.49) | 47(11.96) | 3(4.92) |
Triple-negative | 152(16.63) | 65(16.54) | 9(14.75) |
ER | |||
Positive | 638(69.8) | 277(70.48) | 49(80.33) |
Negative | 276(30.2) | 116(29.52) | 12(19.67) |
PR | |||
Positive | 563(61.6) | 241(61.32) | 41(67.21) |
Negative | 351(38.4) | 152(38.68) | 20(32.79) |
HER2 | |||
Positive | 226(24.73) | 97(24.68) | 10(16.39) |
Negative | 688(75.27) | 296(75.32) | 51(83.61) |
Ki67 | |||
>14% | 768(84.03) | 306(77.86) | 55(90.16) |
≤14% | 146(15.97) | 87(22.14) | 6(9.84) |
P53 | |||
Positive | 654(71.55) | 267(67.94) | 39(63.93) |
Negative | 260(28.45) | 126(32.06) | 22(36.07) |
Ultrasound of axillary lymph nodes | |||
Suspicious | 242(26.48) | 92(23.41) | 22(36.07) |
Normal | 672(73.52) | 301(76.59) | 39(63.93) |
CT scan of axillary lymph nodes | |||
Suspicious | 195(21.33) | 80(20.36) | 12(19.67) |
Normal | 719(78.67) | 313(79.64) | 49(80.33) |
CEA | |||
Elevated | 15(1.64) | 7(1.78) | NA |
Normal | 899(98.36) | 386(98.22) | 61(100) |
CA153 | |||
Elevated | 37(4.05) | 22(5.6) | 3(4.92) |
Normal | 877(95.95) | 371(94.4) | 58(95.08) |
CA125 | |||
Elevated | 32(3.5) | 23(5.85) | NA |
Normal | 882(96.5) | 370(94.15) | 61(100) |
