Table 3 Accelerated stability study of DP at 25 °C.
Time (days) | FA-Fluo | CGE-UV | IP-RPLC | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Fragments | Un-tailed | Main peak | Fragments | Un-tailed | Main peak | Dimer | Fragments | Un-tailed | Main peak | mRNA-LNP | |
0 | 11% | 9% | 80% | 11% | 9% | 70% | 10% | 14% | 9% | 68% | 10% |
2 | 12% | 10% | 78% | 14% | 7% | 60% | 18% | 12% | 5% | 36% | 47% |
7 | 17% | 11% | 72% | 14% | 7% | 62% | 17% | 10% | 2% | 10% | 78% |
9 | 19% | 10% | 71% | 17% | 7% | 57% | 18% | 9% | 1% | 6% | 83% |
13 | 22% | 12% | 66% | 19% | 6% | 58% | 17% | 8% | 1% | 3% | 88% |
15 | 24% | 11% | 65% | 20% | 7% | 56% | 17% | 9% | 1% | 2% | 89% |
