Table 3 Comparison of methods for determination of cobalamins in the literatures.

LC-ICP-MS

Co(II)

0.029 µg/L

0.144 µg/kg

Infant milk powder

Current method

OH-Cbl

0.039 µg/L

0.197 µg/kg

CN-Cbl

0.053 µg/L

0.267 µg/kg

Ado-Cbl

0.042 µg/L

0.209 µg/kg

Me-Cbl

0.056 µg/L

0.278 µg/kg

HPLC-UV^a

CN-Cbl

0.16 mg/kg

Kefir samples

³²

HPLC-ICP-OES^b

Co(II)

0.06 mg/kg

Kefir samples

³²

CN-Cbl

0.07 mg/kg

HPLC-VWD^c

CN-Cbl

0.04 mg/kg

Supplemented foods

¹³

HPLC-DAD^d

CN-Cbl

0.52 mg/L

dietary supplements

¹⁴

HILIC-FLD^e

Total VB₁₂

4 µg/kg

Infant formula

¹

HPLC-ICP-MS^f

Co(II)

0.08 ng/g

Fortified breakfast cereals and multivitamin tablets

²²

CN-Cbl

0.04 ng/g

CE-ICP-MS^g

Co(II)

0.3 ng/mL

Nutritive supplements

and chlorella Foods

³³

OH-Cbl

0.2 ng/mL

CN-Cbl

1.7 ng/mL