Fig. 4
From: Vitisin A inhibits liver fibrosis by promoting Nrf2/HO-1 pathway and inhibiting Cuproptosis
Vitisin A have therapeutic effect on fibrosis and cuproptosis by Nrf2/HO-1 signaling pathway in vivo. (A) Western blot of Nrf2/HO-1 signaling, cuproptosis and fibrosis related proteins in mice treated with Vitisin A. (B) Quantitative analysis of related markers. (C) MDA levels. (D) Liver fat production-related proteins expression. (E) ELISA analysis of fatty acid β-oxidation-related proteins. (F) The efficiency of Nrf2 inhibition by ML385. (G) Quantitative analysis of cuproptosis-related markers. (H) Serum ALT and AST level of mice. (I) Representative image of HE and Masson staining in mice liver tissue. Data are expressed as mean ± SD (n ≥ 5 mice per group). * p < 0.05, ** p < 0.001, *** p < 0.001, **** p < 0.0001.
