Table 1 Basic characteristics in all patients.

From: Construction and validation of a novel model for guiding targeted combined immunotherapy in advanced hepatocellular carcinoma

 

Total

Train

Test

External

P-value

Progression of disease

TIE

239 (73.1%)

110 (72.4%)

53 (77.9%)

76 (71.0%)

0.59

TIN

88 (26.9%)

42 (27.6%)

15 (22.1%)

31 (29.0%)

 

 OS

  Live

239 (73.1%)

110 (72.4%)

53 (77.9%)

76 (71.0%)

0.59

  Die

88 (26.9%)

42 (27.6%)

15 (22.1%)

31 (29.0%)

 

 NLR

  <=3

177 (54.1%)

84 (55.3%)

37 (54.4%)

56 (52.3%)

0.92

  >3

150 (45.9%)

68 (44.7%)

31 (45.6%)

51 (47.7%)

 

 ΔT

  <0

145 (44.3%)

68 (44.7%)

26 (38.2%)

51 (47.7%)

0.48

  >=0

182 (55.7%)

84 (55.3%)

42 (61.8%)

56 (52.3%)

 

 ΔP

  <0

263 (80.4%)

121 (79.6%)

56 (82.4%)

86 (80.4%)

0.92

  >=0

64 (19.6%)

31 (20.4%)

12 (17.6%)

21 (19.6%)

 

 Statelite nodule

  Yes

301 (92.0%)

139 (91.4%)

63 (92.6%)

99 (92.5%)

0.96

  No

26 (8.0%)

13 (8.6%)

5 (7.4%)

8 (7.5%)

 

 Sex

  Male

287 (87.8%)

133 (87.5%)

60 (88.2%)

94 (87.9%)

1

  Female

40 (12.2%)

19 (12.5%)

8 (11.8%)

13 (12.1%)

 

 Echo of tumor

  Homogeneous

211 (64.5%)

92 (60.5%)

46 (67.6%)

73 (68.2%)

0.39

  Heterogeneous

116 (35.5%)

60 (39.5%)

22 (32.4%)

34 (31.8%)

 

 Capsual of tumor

  Clear

40 (12.2%)

21 (13.8%)

5 (7.4%)

14 (13.1%)

0.4

  Obscure

287 (87.8%)

131 (86.2%)

63 (92.6%)

93 (86.9%)

 

 Collateral circulation

  No

244 (74.6%)

110 (72.4%)

57 (83.8%)

77 (72.0%)

0.14

  Yes

83 (25.4%)

42 (27.6%)

11 (16.2%)

30 (28.0%)

 

 AFP

  <200

120 (36.7%)

58 (38.2%)

26 (38.2%)

36 (33.6%)

0.74

  >200

207 (63.3%)

94 (61.8%)

42 (61.8%)

71 (66.4%)

 

 Macrovascular invansion

  No

121 (37.0%)

61 (40.1%)

25 (36.8%)

35 (32.7%)

0.47

  Yes

206 (63.0%)

91 (59.9%)

43 (63.2%)

72 (67.3%)

 

 Viral hepatitis

  Non-HBV

37 (11.3%)

19 (12.5%)

3 (4.4%)

15 (14.0%)

0.1

  HBV

290 (88.7%)

133 (87.5%)

65 (95.6%)

92 (86.0%)

 

Age(years)

51.2 ± 9.5

50.7 ± 9.2

53.6 ± 10.4

50.5 ± 9.3

0.076

ALT(U/L)

108.6 ± 371.4

138.1 ± 535.2

78.1 ± 92.2

86.1 ± 92.0

0.41

AST(U/L)

80.1 ± 63.4

82.3 ± 63.6

74.2 ± 62.8

80.8 ± 64.0

0.68

PLT(/L)

238.0 ± 68.9

241.3 ± 72.0

220.1 ± 59.1

244.6 ± 68.8

0.051

ALB(g/L)

39.8 ± 14.3

38.9 ± 5.4

43.4 ± 29.4

38.9 ± 5.3

0.073

GGT(u/L)

335.0 ± 398.9

358.6 ± 432.9

288.4 ± 280.1

331.2 ± 413.0

0.48

TBIL(umol/L)

35.0 ± 51.1

36.4 ± 53.9

30.3 ± 44.1

36.1 ± 51.5

0.69

ALP(mmol/L)

305.4 ± 271.7

306.4 ± 244.4

273.8 ± 261.7

324.2 ± 312.6

0.49

PT(s)

12.2 ± 0.9

12.1 ± 0.9

12.2 ± 0.8

12.2 ± 0.9

0.62

PTA(%)

110.9 ± 22.1

111.7 ± 23.3

107.6 ± 17.2

112.0 ± 22.9

0.38

INR

1.0 ± 0.3

1.0 ± 0.3

1.0 ± 0.2

1.1 ± 0.4

0.088

BMI

22.8 ± 2.8

23.0 ± 2.8

22.3 ± 2.8

23.0 ± 2.9

0.27

Diameter(cm)

8.4 ± 1.5

8.4 ± 1.5

8.5 ± 1.4

8.2 ± 1.5

0.53

Ostime(days)

132.3 ± 56.0

129.3 ± 58.7

133.7 ± 52.4

135.8 ± 54.4

0.63

  1. TIE: target and immunotherapy effective; TIN: target and immunotherapy noneffective; ΔT: The difference in stiffness of the tumor six weeks after treatment minus the stiffness before treatment.ΔP: The difference in stiffness of the surrounding tissue six weeks after treatment minus the stiffness before treatment.