Fig. 4 | Scientific Reports

Fig. 4

From: Shikonin inhibits multiple tumor malignant phenotypes and is associated with Hedgehog pathway downregulation in lung adenocarcinoma

Fig. 4

SH regulates the expression of DEGs related to tumor malignant phenotypes in A549 cells (TPM, n = 5 (independent cell cultures)). (A, C) Heatmaps of gene expression profiles related to tumor metastasis and EMT based on the RNA-seq data set. (B) Relative mRNA levels of tumor metastasis genes (MAPK1, MAPK14, COL5A1, FN1, EP300, and FOSL2). (D) Relative mRNA levels of EMT genes (CDH2, CDH11, SMAD2, SMAD3, WNT9A, and SP-1). TPM, transcripts per million. *p < 0.05; **p < 0.01; ***p < 0.001 and ****p < 0.0001, compared with Model group, one way ANOVA.

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